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Mind & Personality – Genetic Predispositions Report

Upload your raw DNA data and learn about your genetic risks & predispositions!

$9 USD

Big-5 Personality Traits

These components are generally stable over time, and about half of the variance appears to be attributable to a person’s genetics.

  • openness to experience (inventive/curious vs. consistent/cautious)
  • conscientiousness (efficient/organized vs. extravagant/careless)
  • extraversion (outgoing/energetic vs. solitary/reserved)
  • agreeableness (friendly/compassionate vs. challenging/callous)
  • neuroticism (sensitive/nervous vs. resilient/confident)

Risk tolerance (source: Linnér, 2019)

This study identified hundreds of new genetic variants associated with risky behavior in genes, most of which are highly expressed in the brain. Risk tolerance was measured using various behaviors: adventurousness, automobile speeding propensity, drinks per week, smoking, and the number of sexual partners. Hundreds of genetic variants were identified in or near genes that are highly expressed in the brain and play a role in signaling between neurons.

Attention-deficit/Hyperactivity Disorder (source: Demontis, 2018)

The risk of ADHD is determined by a variety of different genetic and environmental influences. In this genome-wide association study, 12 loci associated with ADHD were identified by examining 55,374 individuals of European ancestry.

Loneliness (source: Abdellaoui, 2019)

Humans are social creatures and feelings of loneliness arise when we don’t feel as socially connected as we want. This study examined more than half a million people of European descent, discovering 19 genetic variants that may be associated with an increased propensity of feeling lonely. These variants help explain ~20% of the heritability of loneliness.

Depression (source: Wray, 2018)

Genetics are a known factor in a person’s risk of developing depression. This study examined 480,359 individuals of European ancestry to identify genetic variants associated with depression. The majority of the variants identified in this study are in genes that are expressed in brain regions known for their role in depression.

Well-being (source: Baselmans, 2019)

Our well-being is a multivariate trait typically characterized by high life-satisfaction, positive affect, and absence of neuroticism as well as depressive symptoms. Using a novel method, this study analyzed the genomes of 160,000 individuals of European ancestry to discover 304 variants associated with well-being. Some of these identified variants are near genes that are highly expressed in brain tissue, specifically in the hippocampus region that plays an important role in regulating memory, learning, and emotion.

Anhedonia (source: Ward, 2019)

Anhedonia refers to a condition characterized by an inability to feel pleasure from activities that are considered enjoyable. This genome-wide study of over 375,000 individuals of European ancestry discovered 11 genomic regions that are associated with feelings of anhedonia. The discovered variants were also found to be associated with smaller volumes of brain regions linked to reward and pleasure processing as well as other structural changes in the brain.

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